Assay Detail
Binding
CHEMBL3994501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition to induce Bim protein expression measured after 24 hrs by Cell Titer-Glo assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (CHEMBL4105824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 6.29 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078870 | — | — | 1 | 9.38 |
| CHEMBL4078220 | — | — | 1 | 8.85 |
| CHEMBL4091379 | — | — | 1 | 7.60 |
| CHEMBL4064603 | — | — | 1 | 7.57 |
| CHEMBL4070501 | — | — | 1 | 7.24 |
| CHEMBL4061878 | — | — | 1 | 7.18 |
| CHEMBL4092330 | — | — | 1 | 7.16 |
| CHEMBL4082074 | — | — | 1 | 7.03 |
| CHEMBL4071549 | — | — | 1 | 6.96 |
| CHEMBL4086114 | — | — | 1 | 6.79 |
| CHEMBL4093871 | — | — | 1 | 6.67 |
| CHEMBL4083596 | — | — | 1 | 6.60 |
| CHEMBL4089942 | — | — | 1 | 6.59 |
| CHEMBL4073188 | — | — | 1 | 6.55 |
| CHEMBL4101603 | — | — | 1 | 6.44 |
| CHEMBL1430895 | — | — | 1 | 6.13 |
| CHEMBL4101046 | — | — | 1 | 6.09 |
| CHEMBL4070722 | — | — | 1 | 5.95 |
| CHEMBL4063455 | — | — | 1 | 5.94 |
| CHEMBL4085084 | — | — | 1 | 5.94 |
| CHEMBL4097841 | — | — | 1 | 5.84 |
| CHEMBL4090123 | — | — | 1 | 5.80 |
| CHEMBL4097672 | — | — | 1 | 5.74 |
| CHEMBL1492648 | — | — | 1 | 5.66 |
| CHEMBL4063532 | — | — | 1 | 5.46 |
| CHEMBL4096202 | — | — | 1 | 5.46 |
| CHEMBL4086039 | — | — | 1 | 5.45 |
| CHEMBL4103147 | — | — | 1 | 5.40 |
| CHEMBL4074296 | — | — | 1 | 5.39 |
| CHEMBL4062092 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078870 | — | EC50 | = | 0.42 | nM | 9.38 |
| CHEMBL4078220 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4091379 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4064603 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4070501 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4061878 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4092330 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4082074 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4071549 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4086114 | — | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4093871 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4083596 | — | EC50 | = | 253.0 | nM | 6.60 |
| CHEMBL4089942 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4073188 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL4101603 | — | EC50 | = | 364.0 | nM | 6.44 |
| CHEMBL1430895 | — | EC50 | = | 749.0 | nM | 6.13 |
| CHEMBL4101046 | — | EC50 | = | 817.0 | nM | 6.09 |
| CHEMBL4070722 | — | EC50 | = | 1135.0 | nM | 5.95 |
| CHEMBL4063455 | — | EC50 | = | 1143.0 | nM | 5.94 |
| CHEMBL4085084 | — | EC50 | = | 1157.0 | nM | 5.94 |
| CHEMBL4097841 | — | EC50 | = | 1428.0 | nM | 5.84 |
| CHEMBL4090123 | — | EC50 | = | 1591.0 | nM | 5.80 |
| CHEMBL4097672 | — | EC50 | = | 1821.0 | nM | 5.74 |
| CHEMBL1492648 | — | EC50 | = | 2201.0 | nM | 5.66 |
| CHEMBL4063532 | — | EC50 | = | 3489.0 | nM | 5.46 |
| CHEMBL4096202 | — | EC50 | = | 3487.0 | nM | 5.46 |
| CHEMBL4086039 | — | EC50 | = | 3516.0 | nM | 5.45 |
| CHEMBL4103147 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4074296 | — | EC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL4062092 | — | EC50 | = | 4207.0 | nM | 5.38 |
| CHEMBL4100077 | — | EC50 | = | 4477.0 | nM | 5.35 |
| CHEMBL4078150 | — | EC50 | = | 6355.0 | nM | 5.20 |
| CHEMBL4104624 | — | EC50 | = | 6642.0 | nM | 5.18 |
| CHEMBL4103961 | — | EC50 | = | 7033.0 | nM | 5.15 |
| CHEMBL4088482 | — | EC50 | = | 8756.0 | nM | 5.06 |
| CHEMBL4080611 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4081324 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4105576 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4089190 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4068001 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4104840 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4067221 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4102499 | — | EC50 | > | 20000.0 | nM | - |