Compound Detail
CHEMBL4070501
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Basic Information
| ChEMBL ID | CHEMBL4070501 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHWISQOBXACORH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
439.4
MW (Da)
2.78
ALogP
7
HBA
0
HBD
91.2
PSA (Ų)
0.57
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial CHEMBL4105824 | EC50 | 7.24 | 7.24 | 57.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | EC50 | = | 57.0 | nM | 7.24 | Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibitio... | 28435527 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28435527 | 10.1021/acsmedchemlett.6b00489 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 2 |
| 28435527 | 10.1021/acsmedchemlett.6b00489 | U2OS | 1 |
Data from ChEMBL 36 via Core Engine