Assay Detail
Binding
CHEMBL3995183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.77 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333021 | L-21649 | 1.0 | 1 | 8.52 |
| CHEMBL324335 | — | — | 1 | 8.40 |
| CHEMBL331465 | — | — | 1 | 8.05 |
| CHEMBL4082186 | — | — | 1 | 7.72 |
| CHEMBL4081227 | — | — | 1 | 7.62 |
| CHEMBL96149 | — | — | 1 | 7.43 |
| CHEMBL92279 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333021 | L-21649 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL324335 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL331465 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4082186 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4081227 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL96149 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL92279 | — | IC50 | = | 224.0 | nM | 6.65 |