Compound Detail
CHEMBL324335
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Basic Information
| ChEMBL ID | CHEMBL324335 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YUAOWJBCURIMGN-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
406.5
MW (Da)
3.84
ALogP
7
HBA
0
HBD
51.9
PSA (Ų)
0.49
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.4 | 8.1533 | 4.0 | 3 |
| Vascular endothelial growth factor receptor CHEMBL2095227 | IC50 | 7.66 | 7.66 | 22.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of Vascular endothelial growth factor receptor 2 | 12443771 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 ce... | 27894044 |
| Vascular endothelial growth factor receptor | IC50 | = | 22.0 | nM | 7.66 | Inhibition of VEGF-stimulated mitogenesis in endothelial cells | 12443771 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 22.0 | nM | 7.66 | Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 ce... | 27894044 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27894044 | 10.1016/j.ejmech.2016.11.019 | Vascular endothelial growth factor receptor 2 | 2 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor 2 | 1 |
| 12443771 | 10.1016/s0960-894x(02)00827-2 | Vascular endothelial growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine