Assay Detail
ADMET
CHEMBL3996775
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Cytotoxicity against CHO cells after by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.33 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.02 |
| CHEMBL1800559 | — | — | 1 | 5.81 |
| CHEMBL4079700 | — | — | 1 | 5.81 |
| CHEMBL4062856 | — | — | 1 | 5.81 |
| CHEMBL4105454 | — | — | 1 | 5.79 |
| CHEMBL4067864 | — | — | 1 | 5.75 |
| CHEMBL4071316 | — | — | 1 | 5.54 |
| CHEMBL4082152 | — | — | 1 | 5.53 |
| CHEMBL4062329 | — | — | 1 | 5.50 |
| CHEMBL4070434 | — | — | 1 | 5.50 |
| CHEMBL4097733 | — | — | 1 | 5.47 |
| CHEMBL4097609 | — | — | 1 | 5.42 |
| CHEMBL4092272 | — | — | 1 | 5.41 |
| CHEMBL4089718 | — | — | 1 | 5.39 |
| CHEMBL4084045 | — | — | 1 | 5.39 |
| CHEMBL4090006 | — | — | 1 | 5.38 |
| CHEMBL4087580 | — | — | 1 | 5.35 |
| CHEMBL4084534 | — | — | 1 | 5.29 |
| CHEMBL4060251 | — | — | 1 | 5.23 |
| CHEMBL4100993 | — | — | 1 | 5.23 |
| CHEMBL4070265 | — | — | 1 | 5.22 |
| CHEMBL4093636 | — | — | 1 | 5.21 |
| CHEMBL4088794 | — | — | 1 | 5.20 |
| CHEMBL4095280 | — | — | 1 | 5.06 |
| CHEMBL4074246 | — | — | 1 | 5.02 |
| CHEMBL4085896 | — | — | 1 | 4.98 |
| CHEMBL4068923 | — | — | 1 | 4.95 |
| CHEMBL4097620 | — | — | 1 | 4.94 |
| CHEMBL4084546 | — | — | 1 | 4.80 |
| CHEMBL4079203 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1800559 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4062856 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4079700 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4105454 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4067864 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4071316 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL4082152 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL4062329 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4070434 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4097733 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4097609 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL4092272 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4089718 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL4084045 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4090006 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4087580 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4084534 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4100993 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL4060251 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4070265 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL4093636 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL4088794 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL4095280 | — | IC50 | = | 8710.0 | nM | 5.06 |
| CHEMBL4074246 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4085896 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4068923 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4097620 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4084546 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4079203 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL4065621 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4070446 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL4099549 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4061812 | — | IC50 | = | 204000.0 | nM | - |
| CHEMBL4081540 | — | IC50 | = | 206000.0 | nM | - |