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Assay Detail

CHEMBL3997100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Induction of glucose-stimulated insulin secretion in mouse MIN6 cells after 2 hrs by ELISA
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type MIN6
Confidence 1 — Organism
Curated By Autocuration

Target

MIN6 (CHEMBL4483258)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives.
Xiao C, Tian Y, Lei M, Chen F, Gan X, Yao X, Shen X, Chen J, Hu L.
Bioorg Med Chem Lett (2017) 27 : 1316 -1318
PubMed 28162858 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 4.54 4.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4089387 1 4.98
CHEMBL4090188 1 4.96
CHEMBL4070788 1 4.90
CHEMBL4100361 1 4.85
CHEMBL4080536 1 4.85
CHEMBL4096956 1 4.73
CHEMBL4097901 1 4.71
CHEMBL4078940 1 4.68
CHEMBL4068207 1 4.49
CHEMBL4098564 1 4.42
CHEMBL4066133 1 4.39
CHEMBL4062171 1 4.38
CHEMBL2001832 1 4.30
CHEMBL4099488 1 4.29
CHEMBL4069849 1 4.21
CHEMBL4086001 1 4.21
CHEMBL4083052 1 4.19
CHEMBL4090277 1 4.09
CHEMBL4090843 1 -
CHEMBL4061180 1 -
CHEMBL4087504 1 -
CHEMBL4081511 1 -
CHEMBL4082343 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4089387 EC50 = 10400.0 nM 4.98
CHEMBL4090188 EC50 = 11000.0 nM 4.96
CHEMBL4070788 EC50 = 12700.0 nM 4.90
CHEMBL4100361 EC50 = 14200.0 nM 4.85
CHEMBL4080536 EC50 = 14200.0 nM 4.85
CHEMBL4096956 EC50 = 18500.0 nM 4.73
CHEMBL4097901 EC50 = 19300.0 nM 4.71
CHEMBL4078940 EC50 = 21000.0 nM 4.68
CHEMBL4068207 EC50 = 32600.0 nM 4.49
CHEMBL4098564 EC50 = 38500.0 nM 4.42
CHEMBL4066133 EC50 = 41000.0 nM 4.39
CHEMBL4062171 EC50 = 41500.0 nM 4.38
CHEMBL2001832 EC50 = 50200.0 nM 4.30
CHEMBL4099488 EC50 = 51000.0 nM 4.29
CHEMBL4069849 EC50 = 62200.0 nM 4.21
CHEMBL4086001 EC50 = 62200.0 nM 4.21
CHEMBL4083052 EC50 = 64300.0 nM 4.19
CHEMBL4090277 EC50 = 80500.0 nM 4.09
CHEMBL4090843 EC50 > 100000.0 nM -
CHEMBL4061180 EC50 > 100000.0 nM -
CHEMBL4087504 EC50 > 100000.0 nM -
CHEMBL4081511 EC50 > 100000.0 nM -
CHEMBL4082343 EC50 > 100000.0 nM -