Assay Detail
Binding
CHEMBL3997541
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Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 2 hrs followed by substrate addition measured every 2 minutes for 50 minutes by Amplex red dye based fluorescence assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.71 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1618272 | — | — | 1 | 7.18 |
| CHEMBL4068784 | — | — | 1 | 6.90 |
| CHEMBL4099444 | — | — | 1 | 6.69 |
| CHEMBL3467241 | — | — | 1 | 6.51 |
| CHEMBL4072524 | — | — | 1 | 6.49 |
| CHEMBL4103840 | — | — | 1 | 6.42 |
| CHEMBL4079586 | — | — | 1 | 6.37 |
| CHEMBL4068773 | — | — | 1 | 6.17 |
| CHEMBL1235374 | — | — | 1 | 6.14 |
| CHEMBL4075843 | — | — | 1 | 6.04 |
| CHEMBL4096085 | — | — | 1 | 6.00 |
| CHEMBL187301 | — | — | 1 | 5.96 |
| CHEMBL4066086 | — | — | 1 | 5.93 |
| CHEMBL1188378 | — | — | 1 | 5.91 |
| CHEMBL1778128 | — | — | 1 | 5.45 |
| CHEMBL148986 | — | — | 1 | 5.44 |
| CHEMBL4098510 | — | — | 1 | 5.30 |
| CHEMBL4060123 | — | — | 1 | 5.22 |
| CHEMBL4088360 | — | — | 1 | 5.09 |
| CHEMBL12392 | — | — | 1 | 4.58 |
| CHEMBL4098672 | — | — | 1 | 4.46 |
| CHEMBL148476 | — | — | 1 | 4.33 |
| CHEMBL610 | PHENETHYLAMINE | — | 1 | 4.22 |
| CHEMBL522 | BENZYLAMINE | — | 1 | 4.19 |
| CHEMBL4084448 | — | — | 1 | - |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | - |
| CHEMBL4084804 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1618272 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4068784 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4099444 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3467241 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4072524 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4103840 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL4079586 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL4068773 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1235374 | — | IC50 | = | 719.0 | nM | 6.14 |
| CHEMBL4075843 | — | IC50 | = | 902.0 | nM | 6.04 |
| CHEMBL4096085 | — | IC50 | = | 999.0 | nM | 6.00 |
| CHEMBL187301 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4066086 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL1188378 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1778128 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL148986 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL4098510 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4060123 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL4088360 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL12392 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4098672 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL148476 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL610 | PHENETHYLAMINE | IC50 | = | 60100.0 | nM | 4.22 |
| CHEMBL522 | BENZYLAMINE | IC50 | = | 64700.0 | nM | 4.19 |
| CHEMBL4084448 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4084804 | — | IC50 | > | 31000.0 | nM | - |