Compound Detail
CHEMBL4103840
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Basic Information
| ChEMBL ID | CHEMBL4103840 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LPEUVSAZSYDINS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
126.1
MW (Da)
0.68
ALogP
2
HBA
1
HBD
38.9
PSA (Ų)
0.56
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysyl oxidase homolog 2 CHEMBL3714029 | IC50 | 6.42 | 6.305 | 385.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysyl oxidase homolog 2 | IC50 | = | 385.0 | nM | 6.42 | Inhibition of full length recombinant human LOXL2 expressed in CHO cells assesse... | 28435530 |
| Lysyl oxidase homolog 2 | IC50 | = | 650.0 | nM | 6.19 | Human LOXL2 Amine Oxidase Activity Assay: LOXL2 amine oxidase activity is evalua... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28435530 | 10.1021/acsmedchemlett.7b00014 | Lysyl oxidase homolog 2 | 1 |
Data from ChEMBL 36 via Core Engine