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Assay Detail

CHEMBL3998366

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK293
Confidence 1 — Organism
Curated By Autocuration

Target

HEK293 (CHEMBL614818)
Type CELL-LINE
Organism Homo sapiens

Publication

Interactions of long-chain homologues of colchicine with tubulin.
Marzo-Mas A, Barbier P, Breuzard G, Allegro D, Falomir E, Murga J, Carda M, Peyrot V, Marco JA.
Eur J Med Chem (2017) 126 : 526 -535
PubMed 27915168 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 8.18 9.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4094083 1 9.77
CHEMBL4075161 1 9.64
CHEMBL4066549 1 9.62
CHEMBL4101825 1 8.82
CHEMBL107 COLCHICINE 4.0 1 8.30
CHEMBL4060240 1 8.15
CHEMBL286731 1 7.87
CHEMBL4082139 1 7.72
CHEMBL4092678 1 7.34
CHEMBL4078460 1 6.61
CHEMBL4104229 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4094083 IC50 = 0.17 nM 9.77
CHEMBL4075161 IC50 = 0.23 nM 9.64
CHEMBL4066549 IC50 = 0.242 nM 9.62
CHEMBL4101825 IC50 = 1.5 nM 8.82
CHEMBL107 COLCHICINE IC50 = 5.0 nM 8.30
CHEMBL4060240 IC50 = 7.1 nM 8.15
CHEMBL286731 IC50 = 13.5 nM 7.87
CHEMBL4082139 IC50 = 18.9 nM 7.72
CHEMBL4092678 IC50 = 46.0 nM 7.34
CHEMBL4078460 IC50 = 244.0 nM 6.61
CHEMBL4104229 IC50 = 766.0 nM 6.12