Assay Detail
Binding
CHEMBL3998916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant MTS-deficient N-terminal His6-tagged and SUMO-tagged Trypanosoma alternative oxidase expressed in Escherichia coli FN102 using ubiquinol-1 as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.65 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086675 | — | — | 1 | 5.87 |
| CHEMBL4098620 | — | — | 1 | 5.84 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 5.23 |
| CHEMBL4080586 | — | — | 1 | - |
| CHEMBL4096176 | — | — | 1 | - |
| CHEMBL4104576 | — | — | 1 | - |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086675 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4098620 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4080586 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4096176 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4104576 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | IC50 | = | 116000.0 | nM | - |