Assay Detail
Binding
CHEMBL3999845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system by Z'-Lyte assay
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.48 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.82 |
| CHEMBL343352 | — | — | 1 | 8.47 |
| CHEMBL4063301 | — | — | 1 | 8.21 |
| CHEMBL4100647 | — | — | 1 | 7.94 |
| CHEMBL4094823 | — | — | 1 | 7.49 |
| CHEMBL4094174 | — | — | 1 | 7.08 |
| CHEMBL4082840 | — | — | 2 | 7.02 |
| CHEMBL4088200 | — | — | 2 | 6.89 |
| CHEMBL4091166 | — | — | 1 | 6.77 |
| CHEMBL4067373 | — | — | 1 | 6.42 |
| CHEMBL1830034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL343352 | — | IC50 | = | 3.38 | nM | 8.47 |
| CHEMBL4063301 | — | IC50 | = | 6.13 | nM | 8.21 |
| CHEMBL4100647 | — | IC50 | = | 11.42 | nM | 7.94 |
| CHEMBL4094823 | — | IC50 | = | 32.35 | nM | 7.49 |
| CHEMBL4094174 | — | IC50 | = | 83.82 | nM | 7.08 |
| CHEMBL4082840 | — | IC50 | = | 94.72 | nM | 7.02 |
| CHEMBL4082840 | — | IC50 | = | 117.5 | nM | 6.93 |
| CHEMBL4088200 | — | IC50 | = | 127.8 | nM | 6.89 |
| CHEMBL4091166 | — | IC50 | = | 169.4 | nM | 6.77 |
| CHEMBL4088200 | — | IC50 | = | 177.8 | nM | 6.75 |
| CHEMBL4067373 | — | IC50 | = | 379.7 | nM | 6.42 |
| CHEMBL1830034 | — | IC50 | > | 10000.0 | nM | - |