Assay Detail
Binding
CHEMBL3999846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain (695-end residues) expressed in insect cells by Z'-Lyte assay
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.40 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.77 |
| CHEMBL343352 | — | — | 1 | 8.39 |
| CHEMBL4063301 | — | — | 1 | 8.16 |
| CHEMBL4100647 | — | — | 1 | 7.77 |
| CHEMBL4094823 | — | — | 1 | 7.31 |
| CHEMBL4094174 | — | — | 1 | 6.95 |
| CHEMBL4082840 | — | — | 2 | 6.95 |
| CHEMBL4091166 | — | — | 1 | 6.88 |
| CHEMBL4088200 | — | — | 2 | 6.83 |
| CHEMBL4067373 | — | — | 1 | 6.43 |
| CHEMBL1830034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL343352 | — | IC50 | = | 4.053 | nM | 8.39 |
| CHEMBL4063301 | — | IC50 | = | 6.963 | nM | 8.16 |
| CHEMBL4100647 | — | IC50 | = | 17.15 | nM | 7.77 |
| CHEMBL4094823 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL4094174 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL4082840 | — | IC50 | = | 112.4 | nM | 6.95 |
| CHEMBL4091166 | — | IC50 | = | 132.1 | nM | 6.88 |
| CHEMBL4088200 | — | IC50 | = | 146.2 | nM | 6.83 |
| CHEMBL4082840 | — | IC50 | = | 174.9 | nM | 6.76 |
| CHEMBL4088200 | — | IC50 | = | 235.6 | nM | 6.63 |
| CHEMBL4067373 | — | IC50 | = | 373.7 | nM | 6.43 |
| CHEMBL1830034 | — | IC50 | > | 10000.0 | nM | - |