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Assay Detail

CHEMBL3999950

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani MHOM/SD/62/ISCL2D axenic amastigotes after 72 hrs by alamar blue assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Synthesis and activity of nucleoside-based antiprotozoan compounds.
Tran HA, Zheng Z, Wen X, Manivannan S, Pastor A, Kaiser M, Brun R, Snyder FF, Back TG.
Bioorg Med Chem (2017) 25 : 2091 -2104
PubMed 28284860 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 51 5.03 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4062813 1 7.22
CHEMBL125 MILTEFOSINE 4.0 1 6.52
CHEMBL4088825 1 6.10
CHEMBL3799380 1 6.06
CHEMBL4075657 1 6.00
CHEMBL4068736 1 5.60
CHEMBL4060076 1 5.04
CHEMBL4074699 1 4.82
CHEMBL4091995 1 4.75
CHEMBL4096088 1 4.66
CHEMBL4093177 1 4.48
CHEMBL4070000 1 4.48
CHEMBL4090399 1 4.43
CHEMBL4076916 1 4.41
CHEMBL3797375 1 4.31
CHEMBL3799800 1 4.29
CHEMBL4099742 1 4.22
CHEMBL3799313 1 4.14
CHEMBL3800333 1 4.00
CHEMBL2113602 1 -
CHEMBL4071448 1 -
CHEMBL3799739 1 -
CHEMBL4080501 1 -
CHEMBL4069803 1 -
CHEMBL3798486 1 -
CHEMBL4067099 1 -
CHEMBL4088363 1 -
CHEMBL4093664 1 -
CHEMBL4066090 1 -
CHEMBL4081985 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4062813 IC50 = 60.0 nM 7.22
CHEMBL125 MILTEFOSINE IC50 = 300.0 nM 6.52
CHEMBL4088825 IC50 = 800.0 nM 6.10
CHEMBL3799380 IC50 = 880.0 nM 6.06
CHEMBL4075657 IC50 = 1000.0 nM 6.00
CHEMBL4068736 IC50 = 2500.0 nM 5.60
CHEMBL4060076 IC50 = 9200.0 nM 5.04
CHEMBL4074699 IC50 = 15000.0 nM 4.82
CHEMBL4091995 IC50 = 18000.0 nM 4.75
CHEMBL4096088 IC50 = 22000.0 nM 4.66
CHEMBL4093177 IC50 = 33000.0 nM 4.48
CHEMBL4070000 IC50 = 33000.0 nM 4.48
CHEMBL4090399 IC50 = 37000.0 nM 4.43
CHEMBL4076916 IC50 = 39000.0 nM 4.41
CHEMBL3797375 IC50 = 49000.0 nM 4.31
CHEMBL3799800 IC50 = 51000.0 nM 4.29
CHEMBL4099742 IC50 = 60000.0 nM 4.22
CHEMBL3799313 IC50 = 73000.0 nM 4.14
CHEMBL3800333 IC50 = 100000.0 nM 4.00
CHEMBL3799415 IC50 = 125000.0 nM -
CHEMBL4102936 IC50 = 173000.0 nM -
CHEMBL4065059 IC50 > 320000.0 nM -
CHEMBL3797470 IC50 > 380000.0 nM -
CHEMBL4073644 IC50 > 280000.0 nM -
CHEMBL4094270 IC50 = 117000.0 nM -
CHEMBL4084731 IC50 = 193000.0 nM -
CHEMBL3800167 IC50 = 208000.0 nM -
CHEMBL4091532 IC50 > 200000.0 nM -
CHEMBL4085977 IC50 > 230000.0 nM -
CHEMBL4105508 IC50 > 240000.0 nM -
CHEMBL4076818 IC50 = 114000.0 nM -
CHEMBL4085214 IC50 > 275000.0 nM -
CHEMBL4097315 IC50 > 200000.0 nM -
CHEMBL4076721 IC50 > 260000.0 nM -
CHEMBL4061466 IC50 > 230000.0 nM -
CHEMBL4100225 IC50 = 139000.0 nM -
CHEMBL4090762 IC50 > 335000.0 nM -
CHEMBL4089844 IC50 = 190000.0 nM -
CHEMBL3799944 IC50 > 353000.0 nM -
CHEMBL4081985 IC50 > 318000.0 nM -
CHEMBL4066090 IC50 = 326000.0 nM -
CHEMBL4093664 IC50 > 335000.0 nM -
CHEMBL4088363 IC50 > 340000.0 nM -
CHEMBL4067099 IC50 = 126000.0 nM -
CHEMBL3798486 IC50 = 148000.0 nM -
CHEMBL4069803 IC50 = 266000.0 nM -
CHEMBL4080501 IC50 = 101000.0 nM -
CHEMBL3799739 IC50 = 199000.0 nM -
CHEMBL4071448 IC50 > 145000.0 nM -
CHEMBL2113602 IC50 = 132000.0 nM -