Assay Detail

CHEMBL4000112

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Antagonist activity at DP2 receptor in CD4-positive human TH2 cells assessed as inhibition of PGD2-induced IL-4 production preincubated for 30 mins followed by PGD2 addition measured after 6 hrs

ChEMBL ↗

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Target

Prostaglandin D2 receptor 2 (CHEMBL5071) ↗

Open DB target context

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Prostaglandin D2 receptor 2 (CHEMBL5071) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin D2 receptor 2

CHEMBL5071

Anchored from Assay target.

Protein identity Prostaglandin D2 receptor 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin D2 receptor 2 (CHEMBL5071) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma.

Sandham DA, Barker L, Brown L, Brown Z, Budd D, Charlton SJ, Chatterjee D, Cox B, Dubois G, Duggan N, Hall E, Hatto J, Maas J, Manini J, Profit R, Riddy D, Ritchie C, Sohal B, Shaw D, Stringer R, Sykes DA, Thomas M, Turner KL, Watson SJ, West R, Willard E, Williams G, Willis J.
ACS Med Chem Lett (2017) 8 : 582 -586
PubMed 28523115 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.51	8.51

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3137332	FEVIPIPRANT	3.0	1	8.51
CHEMBL2442750	QAV680	2.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3137332	FEVIPIPRANT	IC50	=	3.1	nM	8.51
CHEMBL2442750	QAV680	IC50		-	—	-