Assay Detail
Binding
CHEMBL4000116
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Displacement of [3H]NVP-QAW039 from human DP2 receptor expressed in CHO cell membranes by TopCount scintillation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.28 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137332 | FEVIPIPRANT | 3.0 | 1 | 8.99 |
| CHEMBL3931906 | — | — | 1 | 8.72 |
| CHEMBL2442750 | QAV680 | 2.0 | 1 | 7.82 |
| CHEMBL4094939 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137332 | FEVIPIPRANT | Kd | = | 1.023 | nM | 8.99 |
| CHEMBL3931906 | — | Kd | = | 1.905 | nM | 8.72 |
| CHEMBL2442750 | QAV680 | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL4094939 | — | Kd | = | 25.12 | nM | 7.60 |