Assay Detail
Binding
CHEMBL4000360
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Inhibition of BTK in human Ramos cells assessed as inhibition of anti human IgM-induced calcium influx preincubated for 20 mins in dark followed by anti human IgM induction for 8 mins by FLIPR assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolo[2,3-b]pyridine derivatives as potent Bruton's tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.31 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101864 | — | — | 1 | 8.52 |
| CHEMBL4079989 | — | — | 1 | 8.52 |
| CHEMBL4083867 | — | — | 1 | 8.02 |
| CHEMBL4087347 | — | — | 1 | 7.92 |
| CHEMBL4095573 | — | — | 1 | 7.85 |
| CHEMBL4105206 | — | — | 1 | 7.80 |
| CHEMBL3402584 | — | — | 1 | 7.67 |
| CHEMBL4085393 | — | — | 1 | 7.57 |
| CHEMBL2057918 | — | — | 1 | 7.56 |
| CHEMBL4073491 | — | — | 1 | 7.50 |
| CHEMBL4075160 | — | — | 1 | 7.38 |
| CHEMBL4064893 | — | — | 1 | 7.28 |
| CHEMBL4093393 | — | — | 1 | 7.25 |
| CHEMBL4091642 | — | — | 1 | 7.16 |
| CHEMBL4086354 | — | — | 1 | 7.16 |
| CHEMBL4094133 | — | — | 1 | 7.03 |
| CHEMBL4097010 | — | — | 1 | 7.03 |
| CHEMBL4081221 | — | — | 1 | 6.96 |
| CHEMBL4063859 | — | — | 1 | 6.71 |
| CHEMBL4105470 | — | — | 1 | 6.67 |
| CHEMBL4070603 | — | — | 1 | 6.46 |
| CHEMBL4103325 | — | — | 1 | 6.39 |
| CHEMBL4065778 | — | — | 1 | 5.62 |
| CHEMBL4087870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101864 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4079989 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4083867 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4087347 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4095573 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4105206 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3402584 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL4085393 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2057918 | — | IC50 | = | 27.3 | nM | 7.56 |
| CHEMBL4073491 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4075160 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4064893 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4093393 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL4091642 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4086354 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4094133 | — | IC50 | = | 94.2 | nM | 7.03 |
| CHEMBL4097010 | — | IC50 | = | 92.7 | nM | 7.03 |
| CHEMBL4081221 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4063859 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4105470 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4070603 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4103325 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4065778 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4087870 | — | IC50 | > | 5000.0 | nM | - |