Assay Detail
Functional
CHEMBL4000379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells harboring PI3CA H1047R mutant after 72 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.79 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.25 |
| CHEMBL4089891 | — | — | 1 | 6.22 |
| CHEMBL4097092 | — | — | 1 | 6.18 |
| CHEMBL4088969 | — | — | 1 | 6.17 |
| CHEMBL4097625 | — | — | 1 | 6.15 |
| CHEMBL4060710 | — | — | 1 | 6.02 |
| CHEMBL4098014 | — | — | 1 | 5.99 |
| CHEMBL4105333 | — | — | 1 | 5.94 |
| CHEMBL4096535 | — | — | 1 | 5.92 |
| CHEMBL4082582 | — | — | 1 | 5.91 |
| CHEMBL4079071 | — | — | 1 | 5.90 |
| CHEMBL4084993 | — | — | 1 | 5.90 |
| CHEMBL4068201 | — | — | 1 | 5.89 |
| CHEMBL4084553 | — | — | 1 | 5.89 |
| CHEMBL4075213 | — | — | 1 | 5.87 |
| CHEMBL4062875 | — | — | 1 | 5.87 |
| CHEMBL4089383 | — | — | 1 | 5.85 |
| CHEMBL4063347 | — | — | 1 | 5.84 |
| CHEMBL4070327 | — | — | 1 | 5.84 |
| CHEMBL4081081 | — | — | 1 | 5.82 |
| CHEMBL4091254 | — | — | 1 | 5.74 |
| CHEMBL4095616 | — | — | 1 | 5.70 |
| CHEMBL4098987 | — | — | 1 | 5.58 |
| CHEMBL4069304 | — | — | 1 | 5.57 |
| CHEMBL4080959 | — | — | 1 | 5.56 |
| CHEMBL4059556 | — | — | 1 | 5.55 |
| CHEMBL4081506 | — | — | 1 | 5.53 |
| CHEMBL4088838 | — | — | 1 | 5.39 |
| CHEMBL4070452 | — | — | 1 | 5.33 |
| CHEMBL4070920 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4089891 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4097092 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4088969 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4097625 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4060710 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4098014 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4105333 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4096535 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4082582 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4079071 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4084993 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4068201 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4084553 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4062875 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4075213 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4089383 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4063347 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4070327 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4081081 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4091254 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4095616 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4098987 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL4069304 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL4080959 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4059556 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4081506 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4088838 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL4070452 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL4070920 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL4067753 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4061827 | — | IC50 | = | 6090.0 | nM | 5.21 |