Assay Detail
Binding
CHEMBL4000382
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Inhibition of P110beta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.89 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088969 | — | — | 1 | 7.62 |
| CHEMBL4097625 | — | — | 1 | 6.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088969 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4097625 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 421.0 | nM | 6.38 |