Assay Detail
Functional
CHEMBL4000449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MOLM13 cells harboring wild type p53/FLT3-ITD mutant after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.03 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069207 | — | — | 1 | 6.34 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.01 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069207 | — | IC50 | = | 454.2 | nM | 6.34 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 984.9 | nM | 6.01 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 1838.0 | nM | 5.74 |