Assay Detail
Functional
CHEMBL4000452
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Antiproliferative activity against Ara-C resistant human HL60 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.90 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069207 | — | — | 1 | 6.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.88 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069207 | — | IC50 | = | 692.1 | nM | 6.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1331.0 | nM | 5.88 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 2250.0 | nM | 5.65 |