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Assay Detail

CHEMBL4000615

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes by liquid scintillation counter method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Brain
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Kappa-type opioid receptor (CHEMBL3952)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects.
Prezzavento O, Arena E, Sánchez-Fernández C, Turnaturi R, Parenti C, Marrazzo A, Catalano R, Amata E, Pasquinucci L, Cobos EJ.
Eur J Med Chem (2017) 125 : 603 -610
PubMed 27721146 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.76 6.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94350 1 6.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94350 Ki = 175.0 nM 6.76