Assay Detail
Binding
CHEMBL4002259
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Inhibition of recombinant human carbonic anhydrase 1 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.42 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078596 | — | — | 1 | 7.31 |
| CHEMBL4063164 | — | — | 1 | 7.02 |
| CHEMBL4080077 | — | — | 1 | 6.75 |
| CHEMBL4079688 | — | — | 1 | 6.70 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4066940 | — | — | 1 | 6.41 |
| CHEMBL4091049 | — | — | 1 | 6.37 |
| CHEMBL4064210 | — | — | 1 | 6.36 |
| CHEMBL4083255 | — | — | 1 | 6.36 |
| CHEMBL1905680 | — | — | 1 | 6.35 |
| CHEMBL4103944 | — | — | 1 | 6.32 |
| CHEMBL4101260 | — | — | 1 | 6.31 |
| CHEMBL2414438 | — | — | 1 | 6.25 |
| CHEMBL4096617 | — | — | 1 | 6.21 |
| CHEMBL3113927 | — | — | 1 | 6.06 |
| CHEMBL2424832 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078596 | — | Ki | = | 49.2 | nM | 7.31 |
| CHEMBL4063164 | — | Ki | = | 95.7 | nM | 7.02 |
| CHEMBL4080077 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL4079688 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4066940 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL4091049 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL4064210 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL4083255 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL1905680 | — | Ki | = | 446.0 | nM | 6.35 |
| CHEMBL4103944 | — | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL4101260 | — | Ki | = | 491.0 | nM | 6.31 |
| CHEMBL2414438 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL4096617 | — | Ki | = | 617.0 | nM | 6.21 |
| CHEMBL3113927 | — | Ki | = | 865.0 | nM | 6.06 |
| CHEMBL2424832 | — | Ki | = | 5121.0 | nM | 5.29 |