Assay Detail
Binding
CHEMBL4003428
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Inhibition of GST-His tagged human p38alpha expressed in Escherichia coli assessed as reduction in ATF2 phosphorylation measured after 60 mins by ELISA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.43 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062023 | — | — | 1 | 9.10 |
| CHEMBL4086457 | — | — | 1 | 8.70 |
| CHEMBL4082212 | — | — | 1 | 8.52 |
| CHEMBL4092555 | — | — | 1 | 8.52 |
| CHEMBL4069805 | — | — | 1 | 8.40 |
| CHEMBL4074524 | — | — | 1 | 7.77 |
| CHEMBL4085536 | — | — | 1 | 7.77 |
| CHEMBL4093282 | — | — | 1 | 7.66 |
| CHEMBL4072555 | — | — | 1 | 7.58 |
| CHEMBL4063964 | — | — | 1 | 7.46 |
| CHEMBL4077018 | — | — | 1 | 7.44 |
| CHEMBL4066691 | — | — | 1 | 7.42 |
| CHEMBL4101953 | — | — | 1 | 7.33 |
| CHEMBL4071770 | — | — | 1 | 7.00 |
| CHEMBL4092482 | — | — | 1 | 6.90 |
| CHEMBL4104351 | — | — | 1 | 6.83 |
| CHEMBL4094220 | — | — | 1 | 6.66 |
| CHEMBL4077684 | — | — | 1 | 6.62 |
| CHEMBL4082278 | — | — | 1 | 5.71 |
| CHEMBL4100292 | — | — | 1 | 5.23 |
| CHEMBL4101252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062023 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4086457 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4082212 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4092555 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4069805 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4074524 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4085536 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4093282 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4072555 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4063964 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4077018 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4066691 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4101953 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4071770 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4092482 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4104351 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4094220 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4077684 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL4082278 | — | IC50 | = | 1952.0 | nM | 5.71 |
| CHEMBL4100292 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL4101252 | — | IC50 | > | 10000.0 | nM | - |