Assay Detail
Binding
CHEMBL4003520
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Inhibition of PARP4 (unknown origin)
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP4 (CHEMBL6142) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.18 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069447 | — | — | 2 | 4.19 |
| CHEMBL4098188 | — | — | 2 | 4.16 |
| CHEMBL4080163 | — | — | 1 | - |
| CHEMBL1892587 | — | — | 1 | - |
| CHEMBL4063631 | — | — | 1 | - |
| CHEMBL1956162 | — | — | 1 | - |
| CHEMBL4059827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069447 | — | IC50 | = | 64565.42 | nM | 4.19 |
| CHEMBL4069447 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4098188 | — | IC50 | = | 69183.1 | nM | 4.16 |
| CHEMBL4098188 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4080163 | — | IC50 | - | — | - | |
| CHEMBL1892587 | — | IC50 | - | — | - | |
| CHEMBL4063631 | — | IC50 | - | — | - | |
| CHEMBL1956162 | — | IC50 | - | — | - | |
| CHEMBL4059827 | — | IC50 | - | — | - |