Assay Detail
Binding
CHEMBL4003549
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Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan method
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.88 | 8.90 |
| pKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069412 | — | — | 2 | 8.90 |
| CHEMBL4096641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069412 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL4069412 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4096641 | — | pKi | - | — | - |