Assay Detail
Functional
CHEMBL4003673
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Cytotoxicity against human RPMI8226 cells measured after 72 hrs by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.86 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064404 | — | — | 1 | 8.42 |
| CHEMBL4078693 | — | — | 1 | 8.08 |
| CHEMBL4102324 | — | — | 1 | 7.99 |
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 7.88 |
| CHEMBL4094582 | — | — | 1 | 7.86 |
| CHEMBL4099839 | — | — | 1 | 7.80 |
| CHEMBL4061262 | — | — | 1 | 7.77 |
| CHEMBL4072652 | — | — | 1 | 7.69 |
| CHEMBL4104744 | — | — | 1 | 7.68 |
| CHEMBL4078056 | — | — | 1 | 7.68 |
| CHEMBL4082676 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064404 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4078693 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4102324 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4094582 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4099839 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL4061262 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL4072652 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL4104744 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4078056 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4082676 | — | IC50 | = | 22.7 | nM | 7.64 |