Compound Detail
CHEMBL4082676
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)(C)CNC(=O)C[C@H](NC(=O)C1CCN(C(=O)c2ccc(F)cc2)CC1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl
Basic Information
| ChEMBL ID | CHEMBL4082676 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PJHIACOTCUHJGN-LQJZCPKCSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
720.3
MW (Da)
4.80
ALogP
5
HBA
4
HBD
136.7
PSA (Ų)
0.19
QED
1
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
| RPMI-8226 CHEMBL614882 | IC50 | 7.64 | 7.64 | 22.7 | 1 |
| MM1.S CHEMBL4296471 | IC50 | 7.5 | 7.5 | 31.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 2.6 | nM | 8.59 | Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for ... | 28027531 |
| RPMI-8226 | IC50 | = | 22.7 | nM | 7.64 | Cytotoxicity against human RPMI8226 cells measured after 72 hrs by MTS assay | 28027531 |
| MM1.S | IC50 | = | 31.8 | nM | 7.5 | Cytotoxicity against human MM1S cells measured after 72 hrs by MTS assay | 28027531 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28027531 | 10.1016/j.ejmech.2016.12.034 | RPMI-8226 | 1 |
| 28027531 | 10.1016/j.ejmech.2016.12.034 | Proteasome Macropain subunit MB1 | 1 |
| 28027531 | 10.1016/j.ejmech.2016.12.034 | MM1.S | 1 |
Data from ChEMBL 36 via Core Engine