Assay Detail
Binding
CHEMBL4003771
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Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK4 (CHEMBL4203) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.03 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078898 | — | — | 2 | 7.60 |
| CHEMBL4104657 | — | — | 1 | 7.55 |
| CHEMBL4094492 | — | — | 2 | 7.52 |
| CHEMBL4067013 | — | — | 1 | 7.51 |
| CHEMBL4066861 | — | — | 1 | 7.30 |
| CHEMBL4064123 | — | — | 1 | 7.21 |
| CHEMBL4073318 | — | — | 1 | 7.16 |
| CHEMBL4102101 | — | — | 1 | 7.11 |
| CHEMBL4088144 | — | — | 1 | 7.07 |
| CHEMBL4091876 | — | — | 1 | 6.99 |
| CHEMBL367625 | — | — | 1 | 6.98 |
| CHEMBL4082309 | — | — | 1 | 6.91 |
| CHEMBL4084116 | — | — | 1 | 6.52 |
| CHEMBL4080283 | — | — | 1 | 6.30 |
| CHEMBL4104505 | — | — | 1 | 6.20 |
| CHEMBL4100324 | — | — | 1 | 6.19 |
| CHEMBL1532768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078898 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4104657 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4094492 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4067013 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4066861 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4078898 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4064123 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4094492 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4073318 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4102101 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4088144 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4091876 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL367625 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4082309 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4084116 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL4080283 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL4104505 | — | IC50 | = | 634.0 | nM | 6.20 |
| CHEMBL4100324 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL1532768 | — | IC50 | > | 1000.0 | nM | - |