Assay Detail
Binding
CHEMBL4004544
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Inhibition of PKCtheta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | 9.00 |
| CHEMBL4085837 | — | — | 1 | 7.92 |
| CHEMBL4064291 | — | — | 1 | 7.72 |
| CHEMBL4072879 | — | — | 1 | 7.68 |
| CHEMBL4101316 | — | — | 1 | 7.68 |
| CHEMBL4083319 | — | — | 1 | 7.00 |
| CHEMBL4102228 | — | — | 1 | 6.67 |
| CHEMBL4089217 | — | — | 1 | 6.59 |
| CHEMBL4077967 | — | — | 1 | 6.58 |
| CHEMBL4072709 | — | — | 1 | 6.56 |
| CHEMBL4068028 | — | — | 1 | 6.50 |
| CHEMBL4073977 | — | — | 1 | - |
| CHEMBL4083182 | — | — | 1 | - |
| CHEMBL4100747 | — | — | 1 | - |
| CHEMBL4089665 | — | — | 1 | - |
| CHEMBL4078759 | — | — | 1 | - |
| CHEMBL4099609 | — | — | 1 | - |
| CHEMBL4061321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565612 | SOTRASTAURIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4085837 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4064291 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4072879 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4101316 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4083319 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4102228 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4089217 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4077967 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL4072709 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4068028 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL4073977 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL4083182 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL4100747 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL4089665 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL4078759 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL4099609 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL4061321 | — | IC50 | > | 316.0 | nM | - |