Assay Detail
Binding
CHEMBL4004960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length C-terminal His6-tagged Cdk7/recombinant human full-length Cyclin H expressed in baculovirus infected Sf21 insect cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 7/ cyclin H (CHEMBL2111288) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.13 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103249 | — | — | 1 | 5.55 |
| CHEMBL4062554 | — | — | 1 | 5.39 |
| CHEMBL319467 | — | — | 1 | 5.36 |
| CHEMBL4105278 | — | — | 1 | 5.17 |
| CHEMBL4092981 | — | — | 1 | 5.17 |
| CHEMBL4085238 | — | — | 1 | 5.16 |
| CHEMBL4073211 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103249 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4062554 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL319467 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4105278 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4092981 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4085238 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4073211 | — | IC50 | = | 75000.0 | nM | 4.12 |