Assay Detail
Binding
CHEMBL4005478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.88 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081433 | — | — | 1 | 8.43 |
| CHEMBL4074361 | — | — | 1 | 8.38 |
| CHEMBL4101102 | — | — | 1 | 8.12 |
| CHEMBL4085918 | — | — | 1 | 7.82 |
| CHEMBL4082978 | — | — | 1 | 7.70 |
| CHEMBL4102306 | — | — | 1 | 7.38 |
| CHEMBL4079545 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081433 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4074361 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4101102 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4085918 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4082978 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4102306 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4079545 | — | EC50 | = | 45.0 | nM | 7.35 |