Assay Detail
Functional
CHEMBL4005796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of reactive oxygen species production in mouse Neuro2a cells assessed as decrease in H2O2 levels after 6 hrs by ROS-Glo luminescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | N2a |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.57 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.57 |
| CHEMBL4077928 | — | — | 1 | - |
| CHEMBL4085791 | — | — | 1 | - |
| CHEMBL4064236 | — | — | 1 | - |
| CHEMBL4104614 | — | — | 1 | - |
| CHEMBL4078332 | — | — | 1 | - |
| CHEMBL4067419 | — | — | 1 | - |
| CHEMBL4100885 | — | — | 1 | - |
| CHEMBL4073301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590 | MENADIONE | IC50 | = | 2688.0 | nM | 5.57 |
| CHEMBL4077928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085791 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4064236 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4104614 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4078332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4067419 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4100885 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4073301 | — | IC50 | > | 10000.0 | nM | - |