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Assay Detail

CHEMBL4005809

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ADMET
Cytotoxicity against rat L6 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties.
Farahat AA, Kumar A, Say M, Wenzler T, Brun R, Paul A, Wilson WD, Boykin DW.
Eur J Med Chem (2017) 128 : 70 -78
PubMed 28152428 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.23 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL48217 DAPI 1 6.07
CHEMBL167761 1 5.77
CHEMBL4101564 1 5.75
CHEMBL4083558 1 5.70
CHEMBL4075744 1 5.57
CHEMBL4060719 1 5.50
CHEMBL4064561 1 5.35
CHEMBL4103838 1 5.14
CHEMBL4084440 1 4.80
CHEMBL4082595 1 4.67
CHEMBL1650578 1 4.63
CHEMBL4068938 1 4.54
CHEMBL4072114 1 4.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL48217 DAPI IC50 = 860.0 nM 6.07
CHEMBL167761 IC50 = 1700.0 nM 5.77
CHEMBL4101564 IC50 = 1800.0 nM 5.75
CHEMBL4083558 IC50 = 2000.0 nM 5.70
CHEMBL4075744 IC50 = 2700.0 nM 5.57
CHEMBL4060719 IC50 = 3200.0 nM 5.50
CHEMBL4064561 IC50 = 4500.0 nM 5.35
CHEMBL4103838 IC50 = 7200.0 nM 5.14
CHEMBL4084440 IC50 = 15700.0 nM 4.80
CHEMBL4082595 IC50 = 21300.0 nM 4.67
CHEMBL1650578 IC50 = 23500.0 nM 4.63
CHEMBL4068938 IC50 = 29000.0 nM 4.54
CHEMBL4072114 IC50 = 29600.0 nM 4.53