Assay Detail
Binding
CHEMBL4005965
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Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel electrophoresis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.37 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084089 | — | — | 1 | 5.82 |
| CHEMBL4091846 | — | — | 1 | 5.66 |
| CHEMBL4084827 | — | — | 1 | 5.26 |
| CHEMBL583073 | — | — | 1 | 5.22 |
| CHEMBL4064888 | — | — | 1 | 5.16 |
| CHEMBL4092588 | — | — | 1 | 5.09 |
| CHEMBL4102073 | — | — | 1 | - |
| CHEMBL4100323 | — | — | 1 | - |
| CHEMBL4073484 | — | — | 1 | - |
| CHEMBL4074553 | — | — | 1 | - |
| CHEMBL4095021 | — | — | 1 | - |
| CHEMBL4102784 | — | — | 1 | - |
| CHEMBL4103711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084089 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4091846 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4084827 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL583073 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4064888 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4092588 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4102073 | — | IC50 | - | — | - | |
| CHEMBL4100323 | — | IC50 | - | — | - | |
| CHEMBL4073484 | — | IC50 | - | — | - | |
| CHEMBL4074553 | — | IC50 | - | — | - | |
| CHEMBL4095021 | — | IC50 | - | — | - | |
| CHEMBL4102784 | — | IC50 | - | — | - | |
| CHEMBL4103711 | — | IC50 | - | — | - |