Assay Detail
Functional
CHEMBL4006616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human P4R5 cells assessed as reduction in viral infection preincubated with cells for 24 hrs followed by viral infection measured after 48 hrs by fluorescence based beta-galactosidase reporter gene assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.92 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065165 | — | — | 1 | 8.28 |
| CHEMBL4080663 | — | — | 1 | 8.21 |
| CHEMBL4098705 | — | — | 1 | 8.14 |
| CHEMBL4101420 | — | — | 1 | 8.12 |
| CHEMBL436546 | — | — | 1 | 7.96 |
| CHEMBL4071987 | — | — | 1 | 7.96 |
| CHEMBL4093701 | — | — | 1 | 7.85 |
| CHEMBL4095043 | — | — | 1 | 7.58 |
| CHEMBL4103727 | — | — | 1 | 7.41 |
| CHEMBL4066126 | — | — | 1 | 7.41 |
| CHEMBL4074733 | — | — | 1 | 7.32 |
| CHEMBL4068668 | — | — | 1 | 7.23 |
| CHEMBL4092759 | — | — | 1 | 7.19 |
| CHEMBL4085004 | — | — | 1 | 6.68 |
| CHEMBL4079480 | — | — | 1 | 6.38 |
| CHEMBL4064119 | — | — | 1 | 6.37 |
| CHEMBL4090318 | — | — | 1 | 6.10 |
| CHEMBL4063363 | — | — | 1 | 6.08 |
| CHEMBL4095984 | — | — | 1 | 5.62 |
| CHEMBL4073514 | — | — | 1 | 5.62 |
| CHEMBL4100350 | — | — | 1 | 5.39 |
| CHEMBL4062311 | — | — | 1 | 5.28 |
| CHEMBL4073756 | — | — | 1 | 5.00 |
| CHEMBL4094347 | — | — | 1 | - |
| CHEMBL4084111 | — | — | 1 | - |
| CHEMBL4102096 | — | — | 1 | - |
| CHEMBL4091873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065165 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4080663 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4098705 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4101420 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL436546 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4071987 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4093701 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4095043 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4103727 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4066126 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4074733 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4068668 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4092759 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4085004 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4079480 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4064119 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4090318 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4063363 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4095984 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4073514 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4100350 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4062311 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4073756 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4094347 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4084111 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4102096 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4091873 | — | EC50 | > | 15000.0 | nM | - |