Assay Detail
Functional
CHEMBL4006617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human CEM-SS cells assessed as reduction in virus-induced cytopathic effect after 6 days by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.17 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103727 | — | — | 1 | 6.50 |
| CHEMBL4068668 | — | — | 1 | 6.25 |
| CHEMBL4079480 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103727 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4068668 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4079480 | — | EC50 | = | 1800.0 | nM | 5.75 |