Assay Detail
Binding
CHEMBL4006633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Maternal embryonic leucine zipper kinase (CHEMBL4578) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
"Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.17 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077934 | — | — | 1 | 9.82 |
| CHEMBL4088246 | — | — | 1 | 8.96 |
| CHEMBL4071823 | — | — | 1 | 8.82 |
| CHEMBL4092605 | — | — | 1 | 8.82 |
| CHEMBL4085799 | — | — | 1 | 8.06 |
| CHEMBL4066968 | — | — | 1 | 8.04 |
| CHEMBL4095977 | — | — | 1 | 7.92 |
| CHEMBL4065944 | — | — | 1 | 6.92 |
| CHEMBL4093545 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077934 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4088246 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4071823 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4092605 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4085799 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4066968 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4095977 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4065944 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4093545 | — | IC50 | = | 740.0 | nM | 6.13 |