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Assay Detail

CHEMBL4007075

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HRV 1B infected in human HeLa cells after 72 hrs by plaque reduction assay
28
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus 1B
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus A1B (CHEMBL613713)
Type ORGANISM
Organism rhinovirus A1B

Publication

3-Phenylalkyl-2H-chromenes and -chromans as novel rhinovirus infection inhibitors.
Conti C, Proietti Monaco L, Desideri N.
Bioorg Med Chem (2017) 25 : 2074 -2083
PubMed 28242170 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.09 7.60
Activity 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29441 1 7.60
CHEMBL4070591 2 6.32
CHEMBL4091982 2 6.32
CHEMBL4083884 2 6.31
CHEMBL4088765 2 6.27
CHEMBL4071165 2 6.25
CHEMBL4089582 2 6.25
CHEMBL4099727 2 6.15
CHEMBL4095384 2 5.93
CHEMBL4103423 2 5.75
CHEMBL4062154 2 5.62
CHEMBL4061451 2 5.32
CHEMBL4062523 2 5.02
CHEMBL4074950 1 -
CHEMBL4083806 1 -
CHEMBL4075489 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29441 IC50 = 25.0 nM 7.60
CHEMBL4091982 IC50 = 480.0 nM 6.32
CHEMBL4070591 IC50 = 480.0 nM 6.32
CHEMBL4083884 IC50 = 490.0 nM 6.31
CHEMBL4088765 IC50 = 540.0 nM 6.27
CHEMBL4071165 IC50 = 560.0 nM 6.25
CHEMBL4089582 IC50 = 560.0 nM 6.25
CHEMBL4099727 IC50 = 710.0 nM 6.15
CHEMBL4095384 IC50 = 1170.0 nM 5.93
CHEMBL4103423 IC50 = 1790.0 nM 5.75
CHEMBL4062154 IC50 = 2370.0 nM 5.62
CHEMBL4061451 IC50 = 4740.0 nM 5.32
CHEMBL4062523 IC50 = 9590.0 nM 5.02
CHEMBL4074950 IC50 - -
CHEMBL4083806 IC50 - -
CHEMBL4075489 IC50 - -
CHEMBL4070591 Activity - -
CHEMBL4083884 Activity - -
CHEMBL4062154 Activity - -
CHEMBL4062523 Activity - -
CHEMBL4103423 Activity - -
CHEMBL4071165 Activity - -
CHEMBL4091982 Activity - -
CHEMBL4088765 Activity - -
CHEMBL4099727 Activity - -
CHEMBL4089582 Activity - -
CHEMBL4061451 Activity - -
CHEMBL4095384 Activity - -