Assay Detail
Binding
CHEMBL4007540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.22 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521589 | BAMBUTEROL | 3.0 | 1 | 8.37 |
| CHEMBL4098455 | — | — | 1 | 8.15 |
| CHEMBL4096024 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521589 | BAMBUTEROL | IC50 | = | 4.29 | nM | 8.37 |
| CHEMBL4098455 | — | IC50 | = | 7.12 | nM | 8.15 |
| CHEMBL4096024 | — | IC50 | = | 7.28 | nM | 8.14 |