Assay Detail
Binding
CHEMBL4007591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-galactosidase in human PBMC using 4-methylumbelliferyl beta-D-galactopyranoside as substrate at pH 4.3 after 2 hrs by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.84 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085739 | — | — | 1 | 6.75 |
| CHEMBL1818433 | — | — | 1 | 4.92 |
| CHEMBL4081472 | — | — | 1 | - |
| CHEMBL4099495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085739 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1818433 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4081472 | — | IC50 | - | — | - | |
| CHEMBL4099495 | — | IC50 | - | — | - |