Assay Detail
Functional
CHEMBL4007899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells harboring FLT3 ITD mutant after 72 hrs by MTS assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indolin-2-one-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase3 (FLT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.36 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096046 | — | — | 1 | 7.83 |
| CHEMBL4088849 | — | — | 1 | 7.77 |
| CHEMBL3288857 | — | — | 1 | 7.70 |
| CHEMBL4067047 | — | — | 1 | 7.62 |
| CHEMBL4093614 | — | — | 1 | 7.61 |
| CHEMBL4105685 | — | — | 1 | 7.59 |
| CHEMBL3288852 | — | — | 1 | 7.57 |
| CHEMBL4099843 | — | — | 1 | 7.52 |
| CHEMBL3288855 | — | — | 1 | 7.47 |
| CHEMBL4088319 | — | — | 1 | 7.45 |
| CHEMBL4103253 | — | — | 1 | 7.44 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.42 |
| CHEMBL3288858 | — | — | 1 | 7.42 |
| CHEMBL4087794 | — | — | 1 | 7.41 |
| CHEMBL4102022 | — | — | 1 | 7.41 |
| CHEMBL4066041 | — | — | 1 | 7.38 |
| CHEMBL4095622 | — | — | 1 | 7.36 |
| CHEMBL3288854 | — | — | 1 | 7.34 |
| CHEMBL4088463 | — | — | 1 | 7.32 |
| CHEMBL4099542 | — | — | 1 | 7.26 |
| CHEMBL3288856 | — | — | 1 | 7.22 |
| CHEMBL4060630 | — | — | 1 | 7.18 |
| CHEMBL4075219 | — | — | 1 | 7.17 |
| CHEMBL4072964 | — | — | 1 | 7.13 |
| CHEMBL4087920 | — | — | 1 | 7.13 |
| CHEMBL4080036 | — | — | 1 | 7.05 |
| CHEMBL4072640 | — | — | 1 | 6.92 |
| CHEMBL4095502 | — | — | 1 | 6.85 |
| CHEMBL4085444 | — | — | 1 | 6.80 |
| CHEMBL4064042 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096046 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4088849 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL3288857 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4067047 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL4093614 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL4105685 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL3288852 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL4099843 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL3288855 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL4088319 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL4103253 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL535 | SUNITINIB | IC50 | = | 38.5 | nM | 7.42 |
| CHEMBL3288858 | — | IC50 | = | 38.5 | nM | 7.42 |
| CHEMBL4087794 | — | IC50 | = | 39.4 | nM | 7.41 |
| CHEMBL4102022 | — | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL4066041 | — | IC50 | = | 41.4 | nM | 7.38 |
| CHEMBL4095622 | — | IC50 | = | 43.8 | nM | 7.36 |
| CHEMBL3288854 | — | IC50 | = | 45.3 | nM | 7.34 |
| CHEMBL4088463 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL4099542 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3288856 | — | IC50 | = | 60.7 | nM | 7.22 |
| CHEMBL4060630 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL4075219 | — | IC50 | = | 67.8 | nM | 7.17 |
| CHEMBL4072964 | — | IC50 | = | 73.4 | nM | 7.13 |
| CHEMBL4087920 | — | IC50 | = | 74.4 | nM | 7.13 |
| CHEMBL4080036 | — | IC50 | = | 89.9 | nM | 7.05 |
| CHEMBL4072640 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4095502 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4085444 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4064042 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3286422 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4104273 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4103369 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4060228 | — | IC50 | > | 200.0 | nM | - |