Compound Detail
CHEMBL3288857
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Basic Information
| ChEMBL ID | CHEMBL3288857 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ASBKSQMCSYHILW-ATVHPVEESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
396.5
MW (Da)
3.69
ALogP
3
HBA
3
HBD
77.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MV4-11 CHEMBL613835 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MV4-11 | IC50 | = | 20.0 | nM | 7.7 | Antiproliferative activity against human MV4-11 cells harboring FLT3 ITD mutant ... | 28038328 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24904961 | 10.1016/j.ejmech.2014.05.051 | Mus musculus | 3 |
| 24904961 | 10.1016/j.ejmech.2014.05.051 | Aorta | 2 |
| 24904961 | 10.1016/j.ejmech.2014.05.051 | NCI-H460 | 1 |
| 28038328 | 10.1016/j.ejmech.2016.12.038 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine