Assay Detail
Binding
CHEMBL4008014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Aldosterone from MR in rat renal soluble fraction measured after 18 hrs in presence of glucocorticoid receptor antagonist RU-486 by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.28 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087750 | — | — | 1 | 7.66 |
| CHEMBL4085281 | — | — | 1 | 7.51 |
| CHEMBL4095450 | — | — | 1 | 7.22 |
| CHEMBL4066419 | — | — | 1 | 7.21 |
| CHEMBL4075017 | — | — | 1 | 7.08 |
| CHEMBL4079872 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087750 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4085281 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4095450 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4066419 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4075017 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4079872 | — | IC50 | = | 100.0 | nM | 7.00 |