Assay Detail
Binding
CHEMBL4008021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GAL4-fused human PR LBD (680 to 933 residues) expressed in CHO-K1 cells assessed as inhibition of progesterone-induced transactivation activity after 5 to 6 hrs by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.33 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096901 | — | — | 1 | 5.38 |
| CHEMBL4068008 | — | — | 1 | 5.27 |
| CHEMBL2181927 | FINERENONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096901 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4068008 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2181927 | FINERENONE | IC50 | >= | 10000.0 | nM | - |