Assay Detail
Binding
CHEMBL4008048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Aldosterone from human MR overexpressed in FreeStyle 293 cells incubated for 16 hrs by TopCount method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.46 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928876 | — | — | 1 | 6.57 |
| CHEMBL1928875 | — | — | 1 | 6.51 |
| CHEMBL1928872 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928876 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1928875 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1928872 | — | IC50 | = | 510.0 | nM | 6.29 |