Compound Detail
CHEMBL1928876
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Basic Information
| ChEMBL ID | CHEMBL1928876 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LTLHQZAJZVFPBB-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
1
PK Parameters
7
Publications
0
Known Names
Molecular Properties
381.4
MW (Da)
2.85
ALogP
7
HBA
1
HBD
81.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mineralocorticoid receptor CHEMBL1994 | IC50 | 6.57 | 6.57 | 270.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 60.0 | mL.min-1.g-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mineralocorticoid receptor | IC50 | = | 270.0 | nM | 6.57 | Displacement of [3H]aldosterone from cytosolic human MR expressed in HEK293 cell... | 22074142 |
| Mineralocorticoid receptor | IC50 | = | 270.0 | nM | 6.57 | Displacement of [3H]-Aldosterone from human MR overexpressed in FreeStyle 293 ce... | 28051871 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22074142 | 10.1021/jm2011645 | Unchecked | 3 |
| 22074142 | 10.1021/jm2011645 | Mineralocorticoid receptor | 1 |
| 22074142 | 10.1021/jm2011645 | Glucocorticoid receptor | 1 |
| 22074142 | 10.1021/jm2011645 | Androgen receptor | 1 |
| 22074142 | 10.1021/jm2011645 | Progesterone receptor | 1 |
| 22074142 | 10.1021/jm2011645 | Liver microsomes | 1 |
| 28051871 | 10.1021/acs.jmedchem.6b01065 | Mineralocorticoid receptor | 1 |
Data from ChEMBL 36 via Core Engine