Assay Detail
Binding
CHEMBL4008084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant WRN (unknown origin) helicase activity expressed in baculovirus expression system using forked duplex DNA as substrate after 15 mins by polyacrylamide gel electrophoresis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (CHEMBL2146312) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Type I DNA Topoisomerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1374426 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1374426 | — | IC50 | = | 3000.0 | nM | 5.52 |