Assay Detail
Binding
CHEMBL4008167
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Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.74 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103319 | — | — | 1 | 7.50 |
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | 7.40 |
| CHEMBL4093147 | — | — | 1 | 6.68 |
| CHEMBL4065484 | — | — | 1 | 6.66 |
| CHEMBL4096234 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103319 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3414621 | TAZEMETOSTAT | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4093147 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4065484 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4096234 | — | IC50 | = | 3280.0 | nM | 5.48 |