Assay Detail
Functional
CHEMBL4008250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells preincubated with cells for 3 days followed by viral infection by luciferase assay
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.18 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079082 | — | — | 1 | 8.46 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 2 | 7.64 |
| CHEMBL3120793 | GS-6620 | 1.0 | 1 | 6.51 |
| CHEMBL3120789 | — | — | 1 | 6.43 |
| CHEMBL4069270 | — | — | 1 | 5.60 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 5.39 |
| CHEMBL4086934 | — | — | 1 | 5.16 |
| CHEMBL4090316 | — | — | 1 | 4.92 |
| CHEMBL2016758 | — | — | 1 | 4.42 |
| CHEMBL2016760 | — | — | 1 | - |
| CHEMBL4065501 | — | — | 1 | - |
| CHEMBL4066445 | — | — | 1 | - |
| CHEMBL3120779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079082 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3120793 | GS-6620 | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3120789 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4069270 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4086934 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4090316 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2016758 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL2016760 | — | EC50 | > | 88000.0 | nM | - |
| CHEMBL4065501 | — | EC50 | > | 44000.0 | nM | - |
| CHEMBL4066445 | — | EC50 | > | 44000.0 | nM | - |
| CHEMBL3120779 | — | EC50 | > | 44000.0 | nM | - |