Compound Detail
CHEMBL4065501
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Basic Information
| ChEMBL ID | CHEMBL4065501 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APKYEXNSWQWOKS-IOSLPCCCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
292.2
MW (Da)
-2.30
ALogP
10
HBA
4
HBD
163.3
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ebolavirus CHEMBL4434621 | EC50 | 4.25 | 4.25 | 56000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ebolavirus | EC50 | = | 56000.0 | nM | 4.25 | Antiviral activity against GFP-fused Ebolavirus infected in TERT-immortalized HM... | 28124907 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28124907 | 10.1021/acs.jmedchem.6b01594 | Ebolavirus | 1 |
| 28124907 | 10.1021/acs.jmedchem.6b01594 | Human orthopneumovirus | 1 |
| 28124907 | 10.1021/acs.jmedchem.6b01594 | Hepatitis C virus | 1 |
| 28124907 | 10.1021/acs.jmedchem.6b01594 | HEp-2 | 1 |
| 28124907 | 10.1021/acs.jmedchem.6b01594 | Huh-7 | 1 |
| 28124907 | 10.1021/acs.jmedchem.6b01594 | MT4 | 1 |
Data from ChEMBL 36 via Core Engine